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Arizona's Biomedical HubHTML ContentNavy1.00000000000000Arizona's Biomedical Hub<div class="ExternalClassA6CFDB4E6DB944928509941A2FD68319"><html> <div class="ExternalClass5F504BE0FE1A46E7A6C274CE3EB32A85"> <span style="font-size:14.6667px;">As the 5th largest city in the nation, Phoenix boasts institutes of excellence in precision medicine, genomics, molecular medicine, cancer research, healthcare analytics and others. Nowhere is this more concentrated than on the Phoenix Biomedical Campus, 30-acres at the center of Phoenix’s innovator’s core, the PHX Core, in Downtown Phoenix. </span></div><div class="ExternalClass5F504BE0FE1A46E7A6C274CE3EB32A85"><span style="font-size:14.6667px;"><br>Join the frontier of personalized medicine in Phoenix. Unprecedented collaboration between innovators and institutions of excellence sets a new standard. This is the city in which ideas are nurtured, innovation is celebrated, and n​ew explorers are welcome.</span></div> </html></div>1
Explore the PossibilitiesVideoLight Gray2.00000000000000Explore the Possibilities<div class="ExternalClass026728C8E0B94CC0AFE4893D42958BAC"><html> <p> <span id="ms-rterangepaste-start" aria-hidden="true"></span><span id="ms-rterangepaste-start"></span><a target="_blank" href="https://www.youtube.com/watch?v=i5a6yYRY1zc">https://www.youtube.com/watch?v=i5a6yYRY1zc</a>​<span id="ms-rterangepaste-end"></span></p> </html></div>

 

 

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Phoenix Invests Big in Health Care and Biosciences, Hoping to Boost Economy and Add JobsPhoenix Invests Big in Health Care and Biosciences, Hoping to Boost Economy and Add Jobs<div class="ExternalClass472800B53D104192AA9A2774F7E386BD"><html> <p>​</p> <span id="ms-rterangepaste-start"></span> <h4 class="n_gEPV1NTWQkXX0HDg_0 ap_gEPV1NTWQkXX0HDg_0 inheritFontFamily"> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;"> <em style="box-sizing:border-box;">Claudia Whitehead turns from her computer screen and picks up her phone. The caller is the CEO of a Phoenix-based biosciences company calling to tell the program manager in the Phoenix Community and Economic Development Department that it landed $1 million in seed money to advance its contribution in the search to cure cancer. The company needs help in expanding its workforce. ​​​​</em> <br style="box-sizing:border-box;"> </p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;"> <em style="box-sizing:border-box;"></em> <img style="margin:5px;border:0px;width:200px;vertical-align:baseline;max-width:100%;box-sizing:border-box;" alt="Photo, Claudia Whitehead, program manager" src="https://www.phoenix.gov/econdevsite/MediaAssets/STAFF-20180222-Whitehead-Claudia-450PX.jpg" /> <em style="box-sizing:border-box;">To get the ball rolling, Whitehead will confer with a teammate at the Phoenix Business and Workforce Development Center, part of the city's Arizona@Work career program. A representative from GateWay Community College’s LabForce will be swept into that conversation. Within a matter of hours, work begins to set up a custom training program to help the company grow out of its incubator. It's just another service from city of Phoenix to the growing bioscience healthcare industry sector in the city.</em> </p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;"> <em style="box-sizing:border-box;">"Bioscience healthcare has become one of our core industry sectors," said Whitehead. "When we started talking with Amanda Morris, bioscience reporter for The Arizona Republic, it became apparent that Phoenix is a major global center for life-changing bioscience achievements. The work being accomplished with precision medicine and cancer research is like something from science fiction. In Phoenix, we have the ecosystem in bioscience to take the future of medicine from discovery to delivery."</em> <br style="box-sizing:border-box;"> </p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;"> <em style="box-sizing:border-box;">Amanda Morris, the bioscience reporter for the The Arizona Republic, pulls back the curtain and unveils how 7,000 new jobs in bioscience healthcare are to be dispersed around the growth in the sector.</em> <br style="box-sizing:border-box;"> </p> </h4> <h3 style="margin-top:3px;margin-right:0px;margin-bottom:10px !important;margin-left:0px;font-weight:600;font-family:montserrat, "open sans", sans-serif !important;color:rgb(0, 0, 0);font-size:26px;display:block;letter-spacing:-0.4px;line-height:28px !important;box-sizing:border-box;font-style:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;">Companies are investing billions in Phoenix's bioscience and health care industries, which is expected to bring 7,000 new jobs.<br style="box-sizing:border-box;"></h3> <h4 class="n_gEPV1NTWQkXX0HDg_0 ap_gEPV1NTWQkXX0HDg_0 inheritFontFamily"> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;text-align:center;"> <em style="box-sizing:border-box;">By Amanda Morris for The Arizona Republic</em> </p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;">Phoenix recovered more slowly than the rest of the nation after the Great Recession, taking years to recoup lost jobs. <br style="box-sizing:border-box;"></p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;">But this time around, the region might see faster recovery from the COVID-19 recession.<br style="box-sizing:border-box;"></p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;">One big reason is the city’s changing economic landscape, which has begun to rely less on construction and focus increasingly on sectors like health care and bioscience.<br style="box-sizing:border-box;"></p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;">Those industries are more resilient in the face of economic changes, said Christine Mackay, community and economic development director for the city of Phoenix. She said the city has seen significant growth in health care and bioscience over the past few years.<br style="box-sizing:border-box;"></p> <p style="margin-bottom:14px;display:block;font-family:hind, "open sans", sans-serif !important;font-size:16px;line-height:18px !important;box-sizing:border-box;color:rgb(0, 0, 0);font-style:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;background-color:rgb(255, 255, 255);text-decoration-style:initial;text-decoration-color:initial;">​Read the full story in<span> </span><a style="color:rgb(32, 173, 149);text-decoration:none;background:transparent;font-family:hind, sans-serif;transition:all 0.2s ease-in-out 0s;box-sizing:border-box;" href="https://www.azcentral.com/in-depth/news/local/arizona-science/2020/09/13/bioscience-and-health-care-industries-expand-and-add-jobs-phoenix/3392691001/" target="_blank">The Arizona Republic</a>.</p> <br>​<span id="ms-rterangecursor-start"></span><span id="ms-rterangecursor-end"></span><br></h4> <span id="ms-rterangepaste-end"></span> <p> <br> </p> </html></div>
Listen to Phoenix Leaders Share Insights about the Rising Bioindustry in the Nation’s 5th Largest City Listen to Phoenix Leaders Share Insights about the Rising Bioindustry in the Nation’s 5th Largest City <div class="ExternalClass85477EA12D3E483194E93A2800419195"><html> Listen to conversations with Phoenix Mayor Kate Gallego and other leaders as they share their insights with Tom Osha, Senior Vice President of Innovation and Economic Development at Wexford Science+Technology, about Phoenix’s growing and thriving bioindustry ecosystem.<br><br>Listen to these conversations beginning June 8, 2020 <a target="_blank" href="https://wexfordscitech.com/thecommons/"><strong><em>here</em></strong></a>:<br><ul><li><strong>Episode 1 –</strong> <em>The Role of Innovation Districts in Restarting the Economy</em><br></li><li><strong>Episode 2 </strong>– <em>Arizona’s Life Sciences Roadmap</em><br></li><li><strong>Episode 3 </strong>– <em>Phoenix is HOT! And so is the Phoenix Biomedical Campus</em></li><li><strong>Episode 4 </strong>– <em>ASU #1 for Innovation</em></li><li><strong>Episode </strong><strong>5 </strong>– <em>A Fertile Environment for Start-Ups: The OncoMyx Story</em></li><li><strong>Episode </strong><strong>6 </strong>– <em>Building the Life Sciences Workforce</em></li><li><strong>Episode </strong><strong>7 </strong>– <em>The Wexford Knowledge Community</em></li></ul>Sparking collaboration is the purpose of the Phoenix bioindustry ecosystem. Phoenix, Arizona, where each day is a relentless pursuit of cures. From discovery to delivery, join Phoenix companies and the leading edge of personalized medicine. Come to a young, vibrant community in an environment where ideas thrive. With a lack of barriers to enter the market, America’s fastest-growing population, and an entrepreneurial pioneer spirit, this is the place for rising to success. Join Translational Genomics Research Institute, three research universities, and world class bioscientists on the Phoenix Biomedical Campus. Located in dynamic Downtown Phoenix, home to Wexford Science and Technology’s collaboration-designed bioscience research building, the Center for Entrepreneurial Innovation, and unlimited opportunities. Learn more at <a target="_blank" href="/"><strong>www.biomedicalphoenix.com</strong></a> and <a target="_blank" href="https://www.phoenix.gov/econdev/bio"><strong>www.phoenix.gov/econdev/bio</strong> </a> <p> <br> </p> </html></div>
Researchers to Develop Device to Accurately and Quickly Detect COVID-19Researchers to Develop Device to Accurately and Quickly Detect COVID-19<div class="ExternalClass479397C7724A4F61BC30B3F7826EB308"><html> <div style="text-align:center;">​TERESA JOSEPH</div> <p> <br> </p> <div style="box-sizing:border-box;font-family:miloweb, -apple-system, blinkmacsystemfont, "segoe ui", roboto, "helvetica neue", arial, "noto sans", sans-serif, "apple color emoji", "segoe ui emoji", "segoe ui symbol", "noto color emoji";font-weight:700;line-height:1.2;font-size:1.25rem;margin-bottom:1rem !important;color:rgb(33, 33, 33) !important;" class="field field--name-field-subtitle field--type-string field--label-hidden h5 mb-lg-3 text-dark field__item">The Center for Applied NanoBioscience and Medicine Awarded Grant from NASA to Develop Prototype by September 2020</div> <div style="box-sizing:border-box;color:rgb(96, 96, 96);font-size:17px;line-height:23px;margin-bottom:3rem;padding-bottom:1rem;border-bottom:1px solid rgb(96, 96, 96);font-family:miloweb, -apple-system, blinkmacsystemfont, "segoe ui", roboto, "helvetica neue", arial, "noto sans", sans-serif, "apple color emoji", "segoe ui emoji", "segoe ui symbol", "noto color emoji";" class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">Amid the <a style="box-sizing:border-box;background-color:transparent;color:rgb(171, 5, 32);text-decoration-line:underline;transition:all 0.3s ease 0s;" href="https://phoenixmed.arizona.edu/covid-19" target="_blank">coronavirus pandemic</a>, a team of researchers at the University of Arizona College of Medicine – Phoenix are developing a device that will easily and accurately detect COVID-19 in a matter of minutes.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;"> <a style="box-sizing:border-box;background-color:transparent;color:rgb(171, 5, 32);text-decoration-line:underline;transition:all 0.3s ease 0s;" href="https://phoenixmed.arizona.edu/anbm" target="_blank">The Center for Applied NanoBioscience and Medicine</a>, directed by <a style="box-sizing:border-box;background-color:transparent;color:rgb(171, 5, 32);text-decoration-line:underline;transition:all 0.3s ease 0s;" href="https://phoenixmed.arizona.edu/anbm/zenhausern" target="_blank">Frederic Zenhausern, PhD</a>, has received a grant to extend the development of its current space-based health monitoring system to build a prototype for COVID-19 testing by September 2020. The grant for $150,000 is from <a style="box-sizing:border-box;background-color:transparent;color:rgb(171, 5, 32);text-decoration-line:underline;transition:all 0.3s ease 0s;" href="https://www.bcm.edu/academic-centers/space-medicine/translational-research-institute" target="_blank">the Translational Research Institute (TRISH)</a> through NASA Cooperative Agreement NNX16AO69A. Dr. Zenhausern’s lab is working on the project with Dr. Pierre Cosson at the University of Geneva in Switzerland, and Dr. David Aucoin at the University of Nevada in Reno.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">“As cases of the virus continue to increase across the globe, specifically in Arizona, the need for a rapid diagnostic test for the COVID-19 virus is crucial,” Dr. Zenhausern said.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">“TRISH is pleased to see progress on the technology Dr. Zenhausern and his team are making for fast and accurate COVID-19 detection,” Kristin Fabre, PhD, chief scientist at TRISH. “This demonstrates how tools developed for deep space missions, designed specifically to address unknown medical needs, are being applied to address the COVID pandemic.”</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">Currently, the test on market takes several days to get results, due to the requirement for being processed with large automated instrument at centralized laboratories, like Sonora Quest or LabCorp.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">Dr. Zenhausern’s lab is developing a Vertical Flow Assay diagnostic system that can combine genes and antibodies directed to specific viral components of the SARS-Cov-2 onto a paper membrane through which biological fluids can flow and antigen interactions can be detected by the light scattering from gold nanoparticles whose imaging is directly interfaced with a smartphone. A user will self-collect a small finger-prick of blood or a spit of saliva, and then the liquid will be pushed through the paper membrane. Essentially, the device will take a picture of the array of spots from multiplex molecules onto the paper, which then can be analyzed by an algorithm on a cloud server prior to being sent back to the users in less than 15 minutes, telling them if they’ve been exposed to the virus.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">“Our goal is to get a more accurate, comprehensive and faster test out there,” Dr. Zenhausern said. “Testing is extremely important. If we had this kind of device, we would have the capability to test for SARS-COV-2 infection sooner and faster, and we could provide more information moving forward in guiding medical countermeasures for reducing fatalities, better managing health care resources, while bringing people back to safer work environments.”</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">At present, polymerase chain reaction (PCR) and antibody testing are the two major ways that health care systems are testing for COVID-19, and a majority of tests use the gold standard PCR — which detects genetic information of the virus (the RNA) at high sensitivity with less than 200 copies of the virus in a sample; but PCR can only detect if someone is actively infected with the virus, and cannot detect post exposure to the infection. PCR testing for the virus typically includes a nasal swab, which involves a soft brush going up the nose for a few seconds to collect cells and fluids along the passageway.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">Unlike PCR, antibody tests can detect proteins if someone has been previously infected, but recovered from the virus. However, the sensitivity and specificity are limited. The team is using recombinant antigen production technology, which provides a synthetic alternative to the long inoculation of animal models over several months to generate antibodies against the virus. Dr. Zenhausern’s team, comprised of Jerome Lacombe, PhD, and Jian Gu, PhD, partnered with researchers in Geneva who are working to design and validate a pipeline of antibodies against the various proteins of the viral components.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">For example, the spike proteins (S) on the surface of the SARS-COV-2, its membrane protein (M), the nucleo-capsid (N) and the envelope (E) proteins. The team also designed smaller antibody fragments or “nanobodies,” which can be very stable and specific. These reagents have been made available as open source for research and the team has already reported in the literature over a dozen antibodies against COVID N, S, E or M proteins. These biomarkers from the different domains of the virus are typically printed into arrays of spots onto the vertical flow assay membrane, so the biological fluid can be flown through the thickness of the paper and provide enhanced limit of detection by more than 100 times over standard lateral flow immunoassay, such as the common tests commercially available for other health conditions.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">“Through our device, we are combining the benefit of both platforms by increasing capabilities of looking at a much broader panel of disease signatures while significantly increasing the test sensitivity by orders of magnitude,” Dr. Zenhausern said.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">A vertical flow assay test is when the biofluids go toward and through the thickness of the paper, not by capillarity along the length of the test strip. This changes the mechanisms of fluidics and physics, which allows testing to look at multiple biomarkers for a wider range of pathogens, instead of just looking at one target biomarker. “It’s much faster and more sensitive,” Dr. Zenhausern said, “while the volume of the samples can be tuned from a small droplet of blood to a large volume of saliva or urine allowing us to detect low abundance target pathogens without the need for pre-concentrating the specimen prior to run a test.”</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">Already in Arizona and other parts of the world, scientists have discovered a mutated strain of the coronavirus. Mutations can impact diagnostics, but a unique aspect of this platform is the ability to add or modify biomarkers to the test with a high-quality control and fast turn-around-time for production. As more antibodies against coronavirus are detected and as scientists continue to find mutated strains of the virus, researchers can add these markers to the platform and turn it into a large-scale production in the matter of a few weeks.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">According to Dr. Zenhausern, due to the current health crisis, we will need to have rapid testing everywhere that is less invasive and readily deployable at home for more personalized diagnostics.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">“Through this technology, we could deliver point of care diagnostics in a parking lot, hospital emergency room, in an outpatient clinic and at a pharmacy, or even at home, that could run the test in several minutes while delivering secure results,” Dr. Zenhausern said.</p> <p style="box-sizing:border-box;margin-top:0px;margin-bottom:1rem;">Dr. Zenhausern hopes that this platform improves diagnostics not only for COVID-19, but for other viruses and conditions. His team is using a similar technology platform to detect pathogens and Tier 1 biothreats in the Armed Forces, and has worked with NASA TRISH to improve diagnostics for radiation exposure in deep space mission to Mars. Any kind of biological signature, this device could potentially detect. Besides diagnostics, there is also significant potential for building viral nanoparticles as future therapeutic treatment and vaccines.<br></p> </div> <p> <br> </p> </html></div>

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